Travell, Simons & Simons' Myofascial Pain and Dysfunction: The Trigger Point Manual by Joseph Donnelly Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. #Travell, Simons & Simons' Myofascial Pain and Dysfunction: The Trigger Point Manual Joseph Donnelly ebook Travell, Simons & Simons' Myofascial Pain and Dysfunction: The Trigger Point Manual The purpose of this article is to review these new concepts and describe new resulting approaches to the treatment of TrPs.#Travell, Simons & Simons' Myofascial Pain and Dysfunction: The Trigger Point Manual by Joseph Donnelly Scientists are now proposing and reporting the results of new approaches using capsaicin, a vanilloid-receptor agonist, and ACh antagonists (eg, dimethisoquin hydrochloride, botulinum toxin, quinidine, linalool). As an example, Travell and Simons abandoned the application of ischemic compression to TrPs instead the authors adopted several techniques associated with osteopathic medicine (ie, muscle-energy, myofascial, counterstrain high-velocity, low-amplitude). This working hypothesis regarding the etiology of TrPs has changed the approach to treating TrPs. This article expands the proposed etiology to include presynaptic, synaptic, and postsynaptic mechanisms of abnormal depolarization (ie, excessive release of acetycholine, defects of acetylcholinesterase, and upregulation of nicotinic ACh-receptor activity, respectively). New research results suggest that TrPs are evoked by the abnormal depolarization of motor end plates. The proposed etiology of Travell trigger points (TrPs) has undergone a fundamental revision in recent years.
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